Obstetrics & Gynecology - IVF & Infertility
Obstetrics & Gynecology - IVF & Infertility
Dr. Najib Dagher started his medical studies in Bordeaux – France and obtained his MD degree from Odessa State Medical University where he also completed his residency in Obstetrics and Gynecology as well as REPRODUCTIVE ENDOCRINOLOGY - HUMAN REPRODUCTION - Infertility & IVF in 2006.
During his fellowship, Dr. Dagher lectured perinatology and gynecology for students in the Odessa National Medical University from 2004 till 2006.
He then pursued his carrier in many Hospitals in Lebanon. In addition, he occupied in 2007 - 2012 the position of medical and administrative assistant of the chairman of the board of the “Clinique Du Levant” hospital in Beirut. Also, in 2013 Dr. Dagher started to work in Erbil as Medical director & specialist in Gynecology – Obstetrics and erectile dysfunction in men, at “Lebanon Global Clinic”, Erbil - Kurdistan - Iraq.
He became Deputy Medical Director of IVF Lebanon since 1.1.2014 until 12.02.2018.
Success with new technologies
- Women fertility preservation (Social egg freezing)
The embryologist selects a single best looking healthy sperm and injects it directly into the center of each egg. ICSI is used in cases when the quantity or quality of sperm is poor and therefore unable to effectively penetrate the egg on its own. Since fertilization only requires one healthy sperm, ICSI has become one of the most incredible advances in treating severe male factor infertility.
The sperm is selected under a high power light microscope (enhanced by digital imaging) to magnify the sperm sample over 6000 times. With this microscope we can see the internal morphology of the sperm and discard those with abnormalities. According to the WHO a mature sperm should ideally have an oval head with a length of between 4 and 5 microns and a width between 2.5 and 3.5 microns. One healthy sperm is injected into each egg.
IMSI may improve the chances of in vitro fertilization and can be used after several unsuccessful IVFs.
During the first 5 to 7 days of development, the embryo is surrounded and protected by an outer shell called the ZonaPellucida. Normally, when the embryo reaches the uterus, this Zona partially dissolves and the embryo ‘hatches’ and get out, in order to implant in the uterus. In some patients infertility may be caused by a hardening of the Zona, which makes it difficult for the embryo to hatch and implant. Assisted hatching is a laboratory micromanipulation technique carried out just before the embryos are placed in the uterus to help the embryo to hatch from the zona.
The laser assisted hatching is designed to improve the efficiency and success rates of assisted reproductive technology procedures (ART) such as IVF & ICSI.
The unfertilized egg is surrounded by a shell called ZonaPellucida. The Zona has an important role in fertilization. It allows only one sperm to penetrate the Zona and enter the egg to make fertilization. After fertilization of the egg, and during the cleavage stage of an embryo, the ZonaPellucida hardens. This development is normal in order to keep the cells in the egg together. The embryo has to "hatch" or break out and get out of the Zona in order to embed and implant into the endometrium lining of the uterine cavity. This happens about 2-3 days after embryo transfer when the embryo is at the blastocyst stage. Naturally this happens by expanding/contracting of the Zona until it distorts, allowing the blastocyst to "hatch" and get out. When sperm fertilize the eggs in the IVF laboratory, the ZonaPellucida hardens at much faster rate than natural, making it more difficult for the embryo to implant. Before implantation, the embryo has to escape out of its ZonaPellucida by a process called hatching. If this process is not completed properly, implantation failure occurs and a pregnancy is unable to continue.
Assisted hatching consists of creating a hole in ZonaPellucida, to help the embryo in the hatching process. The Laser technology for Assisted Hatching (LAH), where a precision laser beam is focused over the ZonaPellucida making a small opening, between 10-20 microns to facilitate embryo hatching. LAH is done just before the Embryo Transfer. This helps to increase pregnancy rates by improving implantation rates, since embryo hatching is made easier. It’s a fast, and safe method compared to the old method of hatching which was performed by using acidic medium on the Zona to create a small hole. The accuracy of the laser is determined by its programming. There is high degree accuracy.
It is also recommend that thawed embryos (frozen embryos) should be treated with laser assisted hatching before Embryo Transfer to increase success rates.
Who can benefit from Laser Assisted Hatching?
• Patients with day 3 embryos having a thick Zona noted by embryologist.
• Patients with failed previous IVF/ICSI cycles.
• Women older than 35 years of age, have a tendency to produce eggs with a harder ZonaPellucida than younger women.
• Women with a high Follicle Stimulating Hormone (FSH) level.
• Patients having IVF/ICSI for the first time, who are considered poor responders, because they needed a high dose of gonadotropins for poor ovarian response.
• Patients who in previous IVF cycles had low fertilization rate, resulting in three or fewer embryos.
• Patients who ask for laser assisted hatching and are fully informed of its use and function.
• Frozen embryo before transfer.
Testicular sperm aspiration (TESA) is a procedure done for men who are having sperm retrieved for in vitro fertilization/intra-cytoplasmic sperm injection (IVF/ICSI). It is done with local anesthesia in the operating room and is done at the same time with their female partner’s egg retrieval. A needle is inserted in the testicle and tissue/sperm are aspirated. TESA is done for men with obstructive azoospermia or who had vasectomy. If TESA doesn’t provide enough tissue/sperm, an open testis biopsy is needed.
TESE involves making a small incision in the testis and examining the tubules for the presence of sperm. It is either done as a scheduled procedure or is coordinated with their female partner’s egg pickup. TESE is usually performed in the operating room with local anesthesia for men with no sperm in their ejaculation (azoospemia) from a problem with production. Patients usually cryopreserve sperm during this procedure for future IVF/ICSI.
- PGD & sex selection boys or girls – Pre implantation Genetic diagnosis
Preimplantation genetic diagnosis (PGD) is a procedure used in conjunction with in vitro fertilization (IVF) to select embryos free of chromosomal abnormalities and specific genetic disorders for transfer to the uterus. Or for gender selection to choose a boy or a girl. PGD improves the likelihood of a successful pregnancy and birth for two distinctly different groups of patients; couples with infertility related to recurrent miscarriage or unsuccessful IVF cycles and couples who are at risk for passing on an inherited genetic disease to their offspring.
Preimplantation genetic diagnosis may be recommended by your physician when there is a possibility, indicated by your medical history that your embryos could be affected by a genetic disease. PGD can only be performed within the context of an IVF cycle where eggs and sperm, united in the laboratory, develop into embryos.
Today, PGD technology reduces the potential for adverse pregnancy outcomes for couples ‘at risk’ by testing the embryos for certain genetic abnormalities before they are chosen for transfer back to the woman. For example: 10 embryos resulted from an IVF cycle and through PGD testing, six were identified as genetically abnormal and four were normal. Using this knowledge, only the normal embryos will be selected for embryo transfer, reducing the possibility of miscarriage or birth defects.